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Polymorphism in the pharmaceutical industry Rolf Hilfiker
Publisher: Wiley-VCH

It is well-known that calcium atorvastatin (ATV), C66H68CaF2N4O10•3H2O, presents polymorphism. As a case in point, the UK genetic data bank explicitly claims that involvement of the pharmaceutical and biotechnology industry in the project is crucial for its success. Operation design for controlling polymorphism in the anti-solvent crystallization by using ternary phase diagram. The knowledge of the effects of polymorphism of genes for the enzymes involved in drug metabolism, like those belonging to the family of cytochrome P450 can be applied in drug delivery, development and the clinical use of drugs. In Polymorphism in the Pharmaceutical Industry. In Taiwan, the To establish a pharmacogenomic DNA bank and a single nucleotide polymorphisms library3 could be a millstone for Taiwan to develop biomedical and biopharmaceutical industries and then become the main Asian center for clinical trial and drug testing for Chinese populations. Oxford ; Hilfiker, 2006 [Hilfiker, R. Pharmaceutical companies could exclude those people who are known to have a negative response to the drug, from the clinical trials. "Genetic testing is rapidly becoming affordable, and some companies have started offering tests with single nucleotide polymorphism microarrays for less than $300 per person," the researchers say. Operation Anti-solvent or drowning-out crystallization is widely used in the pharmaceutical industry for high yield production. In light of current interest of pharmaceutical industry, the polymorphic Form V is of very much importance (WO 00/32551). In Polymorphism in Molecular Crystals. [0005] In the literature various polymorphic forms of sertraline hydrochloride have been described. Department of Chemistry Polymorph detection and quantification in crystalline materials is a principle interest of the pharmaceutical industry. We report here the dimorphic solid-state structures of the title compound, (II) [link] . Identification and Quantification of Polymorphism in the Pharmaceutical Compound Diclofenac Acid by Terahertz Spectroscopy and Solid-State Density Functional Theory. The benefits of pharmacogenomics are numerous.